Prime Quality, Nature’s Harmony
We aim to be the bridge between science and your wellness, ensuring a brighter future.
Human Experiments
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Clinical Studies
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NMN raw material manufacturers have conducted the largest and most rigorous randomized double-blind blank-controlled clinical trial in the world. A total of 80 healthy people participated. The test results are summarized as follows:
NMN can greatly increase the NAD+ (coenzyme I) content in the body of middle-aged and elderly healthy people. After taking 600 mg of NMN daily for 60 days, the NAD+ content in the human body increased by 400%.
This clinical trial is the first randomized, double-blind human clinical trial in the world to prove that NMN can delay the aging process of biological age in healthy middle-aged and elderly people.
This human clinical study clearly proves that NMN can:
1) greatly increase the physical strength of healthy middle-aged and elderly people;
2) effectively improve the health index of healthy middle-aged and elderly people.
This human clinical trial further proves that daily intake of up to 900 mg of NMN is safe for humans.
For the first time in the world, it has been proven that a daily oral dose of 600mg is the optimal dose for healthy adults.
The research article on the human clinical trial results has been published in the international geriatric research journal «Geroscience» and has received widespread attention.
https://link.springer.com/article/10.1007/s11357-022-00705-1
NMN raw material manufacturers have conducted the largest and most rigorous randomized double-blind blank-controlled clinical trial in the world. A total of 80 healthy people participated. The test results are summarized as follows:
NMN can greatly increase the NAD+ (coenzyme I) content in the body of middle-aged and elderly healthy people. After taking 600 mg of NMN daily for 60 days, the NAD+ content in the human body increased by 400%.
This clinical trial is the first randomized, double-blind human clinical trial in the world to prove that NMN can delay the aging process of biological age in healthy middle-aged and elderly people.
This human clinical study clearly proves that NMN can:
1) greatly increase the physical strength of healthy middle-aged and elderly people;
2) effectively improve the health index of healthy middle-aged and elderly people.
This human clinical trial further proves that daily intake of up to 900 mg of NMN is safe for humans.
For the first time in the world, it has been proven that a daily oral dose of 600mg is the optimal dose for healthy adults.
The research article on the human clinical trial results has been published in the international geriatric research journal «Geroscience» and has received widespread attention.
https://link.springer.com/article/10.1007/s11357-022-00705-1
Formulation
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Based on the physical and chemical properties of different active ingredients, PH’s products include a variety of formulations, such as sustained release, immediate release, and delayed release (enteric-ted type). Their in-vitro dissolutions are shown in the figures below.
Formulation
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Based on the physical and chemical properties of different active ingredients, PH’s products include a variety of formulations, such as sustained release, immediate release, and delayed release (enteric-ted type). Their in-vitro dissolutions are shown in the figures below.
Enteric-coated capsules
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Enteric-coated capsules can greatly improve the bioavailability of NMN. Scientific research has proven that the intestinal absorption of NMN after oral administration is much higher than gastric absorption and sublingual absorption. Oral NMN supplements need to pass through the stomach first and then enter the intestines. The stomach is generally acidic, and NMN is unstable in gastric juice and is easily decomposed. The pH of the intestine is greatly increased, and the stability of NMN in the intestine is also greatly improved. When NMN supplements made of ordinary capsules are taken orally, the ordinary capsules decompose in the stomach and release NMN. As a result, most NMN is destroyed by gastric acid, and only a small amount of unbroken NMN enters the intestine and is absorbed and utilized by the body.
Enteric-coated capsules are not affected by the acidic environment in the stomach. Therefore, after oral administration of enteric-coated NMN capsules, the enteric-coated capsules can smoothly enter the intestines and decompose in the intestines to release NMN, which is then absorbed through the human intestines. In this way, enteric-coated capsules can greatly improve the absorption and utilization rate of NMN in the human body. Please see the picture on the right for further explanation.
Enteric-coated capsules can greatly improve the bioavailability of NMN. Scientific research has proven that the intestinal absorption of NMN after oral administration is much higher than gastric absorption and sublingual absorption. Oral NMN supplements need to pass through the stomach first and then enter the intestines. The stomach is generally acidic, and NMN is unstable in gastric juice and is easily decomposed. The pH of the intestine is greatly increased, and the stability of NMN in the intestine is also greatly improved. When NMN supplements made of ordinary capsules are taken orally, the ordinary capsules decompose in the stomach and release NMN. As a result, most NMN is destroyed by gastric acid, and only a small amount of unbroken NMN enters the intestine and is absorbed and utilized by the body.
Enteric-coated capsules are not affected by the acidic environment in the stomach. Therefore, after oral administration of enteric-coated NMN capsules, the enteric-coated capsules can smoothly enter the intestines and decompose in the intestines to release NMN, which is then absorbed through the human intestines. In this way, enteric-coated capsules can greatly improve the absorption and utilization rate of NMN in the human body. Please see the picture on the right for further explanation.
Improving Bioavailability
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Curcumin itself is not soluble in water and has low bioavailability.
It is an excellent solution for increasing the bioavailability of hydrophobic health promoting ingredients like curcumin, by complexation with cyclodextrins. After the complexation, the ingredient is a highly bioavailable curcumin powder with improved dispersibility in water for various functional food and dietary supplement applications.
Improving bioavailability
—
Curcumin itself is not soluble in water and has low bioavailability.
It is an excellent solution for increasing the bioavailability of hydrophobic health promoting ingredients like curcumin, by complexation with cyclodextrins. After the complexation, the ingredient is a highly bioavailable curcumin powder with improved dispersibility in water for various functional food and dietary supplement applications.
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